FISH-negative, cytogenetically cryptic acute promyelocytic leukemia

FISH-negative, cytogenetically cryptic acute promyelocytic leukemia

Approximately 600–800 new cases of acute promyelocytic leukemia (APL) occur annually in the United States. The advent of all-trans retinoic acid (ATRA) has converted this subtype of acute leukemia to a readily curable one with excellent long-term outcomes. Rapid diagnosis and immediate treatment is crucial in APL and a requirement for favorable prognosis. t(15;17)(q24;q21) is the characteristic...

Acute myeloid leukemia and acute promyelocytic leukemia.

The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...

Acute promyelocytic leukemia?

Briefly, the important clinical findings were as follows: A 10 year old white girl, acutely ill, febrile and showing disseminated skin purpura. There was no visceromegaly. The disease had apparently started 3 weeks before, with epistaxis and other purpuric manifestations. Laboratory findings showed severe anemia and thrombocytopenia with a leukocyte count of 3500 per cu. mm. The differential co...

[Acute promyelocytic leukemia].

Acute promyelocytic leukemia.